Why Thermal Dose Matters in Hyperthermia Therapy

After injection, the Rigvir virus replicates inside tumor cells and destroys them (oncolysis). When tumor cells rupture, Rigvir is released and spreads to nearby tumor cells.

For more than 20 years, menopausal hormone therapy (MHT) has carried a boxed warning about cardiovascular disease, breast cancer, dementia, and other serious health risks. This warning was based largely on findings from the Women’s Health Initiative (WHI) trial—specifically the arm studying oral conjugated equine estrogens (CEE) combined with medroxyprogesterone acetate (MPA). It is critical to clarify what the WHI actually studied. The estrogen used was equine-derived, not human or bioidentical estradiol, and it was administered orally, combined with a synthetic progestin (MPA). Despite these very specific exposures, the concerning findings from this single formulation and route of administration were rapidly expanded by the FDA—without direct clinical evidence—to include all estrogen-containing hormone therapies, regardless of hormone type, dose, formulation, or route of administration. The Problem With a One-Size-Fits-All Black Box The boxed warning treats all hormone therapy products as if they pose identical risks. This includes local, nonsystemic therapies, such as low-dose vaginal estrogen, which have minimal systemic absorption. It also assumes that all women carry the same level of risk when using hormone therapy. This approach does not support individualized care. In fact, it actively undermines it. The black box warning is often the first—and sometimes only—thing patients see. Its stark language creates fear and confusion, making it difficult for clinicians to explain meaningful differences between hormone formulations, routes of administration, timing of initiation, and individual risk profiles. Rather than facilitating shared decision-making, the warning becomes a barrier to it. The consequences have been profound. Since the early 2000s, hormone therapy use has declined by an estimated 70%–80%, even among women who …

In December 2025, the U.S. Food and Drug Administration (FDA) approved a label update for the long-acting injectable contraceptive depot medroxyprogesterone acetate, commonly known as Depo-Provera. The updated label warns of a potential increased risk of meningioma, a type of tumor affecting the protective lining of the brain. This update reflects emerging scientific evidence and underscores the importance of informed, individualized decision-making when considering long-term hormonal therapies. What Is a Meningioma? A meningioma is a tumor that develops in the meninges, the membranes surrounding the brain and spinal cord. While many meningiomas are benign, they can still cause symptoms such as headaches, vision changes, seizures, or cognitive effects depending on size and location. From a longevity and brain-health perspective, even benign tumors are clinically relevant due to their potential impact on neurological function and quality of life over time. What Does the Research Show? The FDA’s label change was prompted by findings from large population-based studies evaluating hormonal contraceptive exposure: Although these studies are observational and do not establish causation, the consistency of findings across large datasets led regulators to update product labeling. Which Depo-Provera Products Are Affected? The updated FDA warning applies to both formulations manufactured by Pfizer: An Integrative and Longevity-Focused Perspective At Bionuu, we view hormone therapies through a systems-based lens. Hormones influence not only reproductive health, but also: This FDA update highlights a key integrative principle: the timing, duration, and cumulative exposure to hormones matter. While Depo-Provera remains an effective option for some individuals, long-term use—particularly later in reproductive life—should be periodically reassessed. …

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